Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia
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چکیده
منابع مشابه
Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia.
Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and sepsis. For this purpose, pneumonia was induced in wild-type (WT) and gzmA-defic...
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Klebsiella pneumoniae is a common cause of nosocomial pneumonia. Osteopontin (OPN) is a phosphorylated glycoprotein involved in inflammatory processes, some of which is mediated by CD44. The aim of this study was to determine the role of OPN during K. pneumoniae-induced pneumonia. Wild-type (WT) and OPN knockout (KO) mice were intranasally infected with 10⁴ colony forming units of K. pneumoniae...
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Pneumonia presenting at birth or occurring within first 48 hours of life is most commonly caused by E. coli, Streptococci, Klebsiella aerobacter or Enterococci(1). Congenital pneumonia produces intrauterine death in 16-20% of neonates(l). Early diagnosis and adequate treatment can reduce the mortality to a great extent. We report a case of congenital pneumonia caused by Klebsiella pneumoniae wi...
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Bacterial surface carbohydrates are important pathogenic factors in gram-negative pneumonia infections. Among these factors, O antigen has been reported to protect pathogens against complement-mediated killing. To examine further the role of O antigen, we insertionally inactivated the gene encoding a galactosyltransferase necessary for serotype O1 O-antigen synthesis (wbbO) from Klebsiella pneu...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2016
ISSN: 1662-811X,1662-8128
DOI: 10.1159/000443401